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Antihistamines

Last Updated July 2022 | This article was created by familydoctor.org editorial staff and reviewed by Leisa Bailey, MD

Antihistamines are medicines that help stop allergy symptoms. These symptoms include:

  • Itchy eyes
  • Sneezing
  • Runny nose or congestion
  • Skin rashes such as hives

They are normally taken by mouth. They come in tablets, capsules, chewable tablets, and liquids. Many people buy them over the counter (OTC) at a store. You can also get them through a prescription from your doctor.

Antihistamines are generally considered safe for most people. This includes adults, children over the age of 2, and older people. If you are pregnant or breastfeeding, ask your doctor if antihistamines are safe for you. Ask your doctor if antihistamines are safe if you have a chronic disease or condition. This includes heart disease, diabetes, or high blood pressure.

Path to improved health

You can take antihistamines in different ways depending on your symptoms. Some people take them only when they have symptoms. Others experience symptoms every day, so they take the antihistamine every day. Sometimes people take them before they are going to be exposed to something they are allergic to. This could include an animal (such as cats or dogs) or certain kinds of plants or flowers.

There are many different brands of antihistamines that you can buy over the counter. Some work in different ways. For example, some are designed to work for 4 to 6 hours. Others last for 12 to 24 hours. Make sure you read the label carefully. Follow the directions for how often to take the antihistamine.

Ask your doctor which OTC antihistamine is best for you based on your symptoms.

If you have severe allergies or allergies that affect you year-round, tell you doctor. It could be that you need a prescription allergy medication. The difference between these at OTCs is that prescription antihistamines can come in higher doses.

Things to consider

Like most medicines, antihistamines can cause side effects. The most common include:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Blurry vision
  • Decreased appetite
  • Feeling nervous, irritable, or excited

Some types of antihistamines can cause sleepiness. Do not drink alcohol when taking antihistamines.

Can I take my prescription antihistamine with other medicines?

You shouldn’t take prescription antihistamines if you also are taking certain other prescription medicines. These include erythromycin (an antibiotic), or certain medicines used to treat fungal infections. These include itraconazole or ketoconazole. When your doctor gives you a prescription, always ask if it’s safe to use with the other medicines you’re taking. Your pharmacist can also tell you what is safe to take. If you aren’t sure, ask the pharmacist or your doctor before taking another medicine.

Can I share my prescription antihistamines with friends who have allergies?

No. Even if your friend has a similar allergy, do not share your medicine. You should never share a prescription medicine with another person. Your doctor has examined you and has picked a medicine that is right only for your problem. Some antihistamines can cause serious side effects if they are given to people who are taking another medicine, or who should not take antihistamines for another reason.

Questions to ask your doctor

  • Do I need an antihistamine?
  • Can I take one over the counter, or do I need a prescription?
  • Which over-the-counter type of antihistamine is the best for my symptoms?
  • What are the side effects of this type or brand?
  • Is there anything I should avoid doing while I’m taking an antihistamine?
  • How long should I take it?

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