Last Updated January 2021 | This article was created by editorial staff and reviewed by Deepak S. Patel, MD, FAAFP, FACSM

What is pseudogout?

Pseudogout is a type of arthritis that causes painful swelling in one or more of your joints. It can lead to joint damage if left untreated.

Pseudogout is similar to a condition called gout. However, gout typically affects the joint in the big toe. Pseudogout usually affects larger joints, such as your knees. Also, pseudogout is caused by the buildup of calcium pyrophosphate dihydrate crystals in your joints, while gout is caused by a buildup of uric acid.

Symptoms of pseudogout

Pseudogout causes pain, swelling, stiffness, and warmth in large joints. It most commonly affects the knees, but it can also affect the elbows, ankles, wrists, shoulders, or hands. Pseudogout attacks can be sudden, and the symptoms may last for days or weeks. Some people who have pseudogout don’t have any symptoms between attacks. In other cases, pseudogout can cause constant pain and discomfort. This chronic (long-lasting) pseudogout may seem similar to osteoarthritis or rheumatoid arthritis.

What causes pseudogout?

Pseudogout develops when deposits of calcium pyrophosphate dihydrate crystals build up in the cartilage (tissue that protects your bones) of a joint. The cause of this buildup is often unknown. The crystals are then released into the fluid in your joint. This causes joint pain and swelling.

Who is at risk of pseudogout?

You may be at higher risk of pseudogout as you get older (especially older than 70 years of age). You may also be at higher risk if you have:

  • A history of pseudogout in your family
  • Too much iron in your blood (called hemochromatosis)
  • Low magnesium levels
  • Overactive parathyroid (called hyperparathyroidism)
  • Too much calcium in your blood (called hypercalcemia)
  • Osteoarthritis

How is pseudogout diagnosed?

Your doctor may draw fluid from your joint to check for the crystals that cause pseudogout. X-rays might also show some buildup of crystals or signs of joint damage. Your doctor will probably want to rule out other possible causes of your symptoms, such as gout, osteoarthritis, or rheumatoid arthritis.

Can pseudogout be prevented or avoided?

Treatment can relieve the symptoms of pseudogout and slow or prevent damage to your joints. Unfortunately, no treatment can get rid of the crystal deposits that cause pseudogout. Taking low doses of colchicine may help to reduce your risk of future attacks. Your doctor can talk to you about the risks and benefits of taking this medicine.

If another condition, such as a thyroid problem, caused your pseudogout, treating that condition may help to make the symptoms of pseudogout less severe. It may also make flare-ups less frequent.

Pseudogout treatment

Your doctor may suggest using a nonsteroidal anti-inflammatory drug (called an NSAID) to treat pain and swelling. These include ibuprofen (two brand names: Advil, Motrin) or naproxen (one brand name: Aleve). For severe attacks, your doctor may prescribe a prescription-strength NSAID such as indomethacin. If you can’t take NSAIDs, your doctor may prescribe a medicine called colchicine to reduce pain and swelling.

If you have kidney problems or a history of stomach ulcers, you should not take anti-inflammatory medicines. You also should not take them if you are taking blood thinners. In these cases, the doctor may inject the affected joint with a shot of cortisone. Cortisone is a type of steroid that reduces pain and swelling.

Your doctor may drain fluid from your joint to relieve your symptoms. This method is called joint aspiration. It is often used along with cortisone shots.

Your doctor may recommend that you limit physical activity while you are having symptoms of a pseudogout attack.

If your joints become badly damaged by pseudogout, surgery may be necessary to repair or replace them.

Living with pseudogout

There is no cure for pseudogout. You should be able to manage your symptoms, though. Talk to your doctor to see what treatment options are best for you. A good management program can offer you relief from the pain. It also may improve joint function.

Questions to ask your doctor

  • What treatment is best for me?
  • When can I expect my symptoms to improve?
  • Am I at risk for long-term joint damage?
  • Am I at risk for other types of arthritis?
  • What lifestyle changes can I make at home to relieve my pain and slow joint damage?