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Diabetes Insipidus

Last Updated October 2023 | This article was created by familydoctor.org editorial staff and reviewed by Daron Gersch, MD, FAAFP

What is diabetes insipidus?

Despite the name, diabetes insipidus is not related to type 1 or type 2 diabetes. Diabetes insipidus is a hormone disorder. It occurs when your body doesn’t produce enough antidiuretic hormone (ADH). It can also occur if your body doesn’t use the hormone effectively. ADH helps your body balance water in the urine and blood.

Symptoms

There are several symptoms of diabetes insipidus, including:

  • Extreme thirst
  • Increased urine production up to 16 quarts a day
  • Getting up multiple times in the night to urinate or wetting the bed
  • Confusion and changes in alertness due to dehydration

What causes diabetes insipidus?

Diabetes insipidus has several causes. In some people, a part of the brain (called the hypothalamus) doesn’t make enough ADH. In other cases, the pituitary gland doesn’t release enough of the hormone. Damage to either the hypothalamus or the pituitary gland can cause diabetes insipidus. This can occur after a head injury, during brain surgery, or when a tumor grows on the glands.

Abnormalities in the kidneys can also cause diabetes insipidus. This can affect the way they process ADH. Diabetes insipidus can be caused by some medicines, such as lithium. About 30% of the time, doctors can’t find the cause.

Diagnosis

To check for diabetes insipidus, your doctor may order one of several tests:

  • A urine test. This will show how much water is in your urine. It can rule out type 1 or type 2 diabetes. (If you have type 1 or type 2 diabetes, there will be excess sugar in your urine.)
  • A blood test. This will check for high sodium levels – another indication of diabetes insipidus.
  • A water deprivation test. This test can take several hours. You aren’t allowed to drink any liquids during this time. Your weight, urine and blood will be checked every hour.
  • An MRI (magnetic resonance image) scan. The scan can show problems in the brain that could be causing your diabetes insipidus.

Can diabetes insipidus be prevented or avoided?

Most of the time, diabetes insipidus is a permanent condition. You likely won’t be able to prevent it. It is often associated with another health problem, such as abnormal kidney function or tumors. Even though you can’t prevent it in these cases, you can often manage the symptoms.

Treatment

If your symptoms are mild, you might not need treatment. However, your doctor will want to check on you more often. You should make sure you always have something to drink. This will ensure that your body doesn’t get dehydrated.

For more severe cases of diabetes insipidus, your doctor may prescribe medicine. This medicine will help your body produce or more effectively use ADH. One medicine called desmopressin is a synthetic form of ADH. It comes in pill form, as a shot, or as a nasal spray. Drinking too much while taking this medicine can overload your body with fluids. This can make you feel sick, weak, or dizzy.

Other treatments will depend on the cause of the illness:

  • If it is caused by kidney problems: Your doctor may recommend that you reduce salt in your diet. You’ll also need to drink enough water to avoid dehydration. Medicines like water pills may help your body balance salt and water.
  • If it is caused by tumors or abnormal growths on your hypothalamus or pituitary gland: Your doctor may suggest surgery to remove the growths.
  • If a medicine is causing diabetes insipidus: Your doctor may prescribe another type. He or she will look for a medicine that won’t cause excessive thirst and urination.

Talk to your doctor about which option is right for you.

Living with diabetes insipidus

There is no cure for diabetes insipidus. But you can work with your doctor to manage the symptoms. Medicine can help prevent the constant thirst and excessive urination that comes with this condition. Preventing these symptoms will add a great deal to your quality of life.

Questions to ask your doctor

  • What is the likely cause of my diabetes insipidus?
  • What’s the best treatment option for me? Will I need medicine? Surgery?
  • What are the risks and benefits of this treatment option?
  • How soon can I expect my symptoms to go away?
  • Does diabetes insipidus put me at risk for any other health problems?
  • Do I need to make any lifestyle changes?

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