COVID-19 Vaccine Frequently Asked Questions

What is an mRNA vaccine and how does it work?

Most vaccines (or immunizations) work by injecting a weakened form of a disease germ into your body. This is usually done with a shot in the arm or leg. Your body detects these germs and makes antibodies to fight them. Those protective antibodies then stay in your body for a long time. In many cases, they stay for the rest of your life.

A messenger ribonucleic acid (mRNA) vaccine is a different kind of vaccine. It works by giving your cells instructions that tell them to make a special protein called a “spike protein.” Your body’s immune cells respond to this spike protein just like they would to a weakened disease germ from a regular vaccine. They make antibodies to fight it. The spike protein instructions in the COVID-19 mRNA vaccine help your body make antibodies that prevent the virus that causes COVID-19 (called SARS-CoV-2) from entering your cells and causing disease. This keeps you from getting sick.

The instructions from the mRNA vaccine don’t interact with your DNA in any way. In fact, once the instructions are copied, your body quickly breaks down the mRNA and removes it from your system.

Can an mRNA vaccine cause COVID-19?

No. The mRNA vaccine doesn’t actually contain the virus that causes COVID-19 and can’t cause disease.

When will a vaccine be available?

Two vaccines  for COVID-19 have been authorized for emergency use in the United States. The U.S. Food and Drug Administration (FDA) has given emergency use authorization (also called EUA) to mRNA vaccines developed by Pfizer-BioNTech and Moderna. The Centers for Disease Control and Prevention (CDC) has recommended the Pfizer-BioNTech vaccine for people 16 and older and the Modern vaccine for people 18 and older.

The first COVID-19 vaccine in the United States was given on December 14, 2020. Health care workers and residents of long-term care facilities will be the first groups to get the vaccine. The next groups of people to get the vaccine will be frontline essential workers and people 75 years and older. Eventually, a vaccine will be available for everyone. For now, the supply is limited.

What is the difference between emergency use authorization and approval by the FDA?

FDA emergency use authorization is used for a medicine or vaccine when limited long-term data is available, but the benefits have been shown to outweigh the risks. EUAs can only be used during a public health emergency, such as the COVID-19 pandemic. Vaccines authorized with an EUA will continue to be studied. Additional safety monitoring and education are also required.

Why should I get a COVID-19 vaccine?

Clinical trials for both vaccines showed that they were over 94% effective at preventing COVID-19. By getting vaccinated, you are reducing your risk of disease, hospitalization, severe complications, and even death. You are also helping prevent the health care system from being even more overwhelmed.

How much does it cost to get the vaccine?

The federal government is providing the COVID-19 vaccine to the American public free of charge. This includes people who have insurance, including Medicare, Medicare Advantage, group or individual health insurance plans, and high-deductible health plans. It also includes people who don’t have health insurance.

During the public health emergency, insurance companies are required to cover the cost of giving the COVID-19 vaccine with no copay, deductible, or coinsurance for the patient. (Note that grandfathered health plans are allowed to opt out of covering the cost of giving the COVID-19 vaccine.) You do not have to pay to get the COVID-19 vaccine, even if you get it from a vaccine provider that isn’t in your insurance network.

 How many doses are needed?

Both vaccines require 2 doses, delivered by a syringe (a shot). The shots are scheduled 3-4 weeks apart, depending on which vaccine you receive. Even though the vaccines are similar, you should get the same vaccine both times.

What are the side effects of the vaccine?

The mRNA vaccine can cause mild symptoms in some people. This happens because the spike protein instructions tell the immune cells to make antibodies. The most common reactions to the vaccine are pain at the injection site, feverfatigue, headache, and muscle aches. These side effects are very common with other vaccines, including the flu shot. They are a sign that the body is responding the way it should to a vaccine.

In rigorous clinical trials, the vaccines showed no serious safety concerns or severe side effects. However, the CDC and the FDA will monitor for side effects as the vaccine is distributed to the public. There have been a small number of people who had a severe allergic reaction (anaphylaxis) to one of the vaccines, but this is rare, and most people will not have any issues. You will be asked about any history of reactions to vaccines or other injections just to be safe. If you have concerns or questions about any side effects after getting the vaccine, check with your family doctor.

How long does immunity last?

We still don’t know how long immunity lasts after you get the mRNA vaccine. We also don’t know how long immunity lasts after natural infection with the virus that causes COVID-19. There are some reports of lower levels of protective antibodies as soon as 3 months after infection. A few cases of reinfection have also been reported. We do know that being infected with seasonal coronaviruses (a source for the common cold) does not give very long-lasting immunity. This is part of the reason seasonal colds are so common every year.

Do I still need to wear a mask and physically distance if I get the vaccine?

Yes! The vaccine protects you from getting sick by keeping the SARS-CoV-2 virus from entering your cells and causing COVID-19. But the vaccine does not keep you from getting the virus and possibly spreading it. Also, it takes a few weeks after the second dose of the vaccine to get the best protection.

Everyone will still need to wear a mask and practice physical distancing until enough people have been vaccinated and developed immunity. This may not be until late 2021. Even then, more data will be needed to see how long immunity lasts. More rounds of COVID-19 vaccination may be needed.

Should I get the vaccine if I’ve already had COVID-19?

Yes, as long as you are not currently sick. We know that natural immunity to the virus that causes COVID-19 decreases over time. There’s not enough information from the COVID-19 vaccine studies to show how immunity from the vaccine compares to natural immunity. It’s likely the vaccine will boost your immunity and keep you protected longer.

Who can’t get the vaccine?

Children and adolescents under age 16 were not included in the first round of vaccine studies. For this reason, only people 16 and older will be able to get the Pfizer vaccine. Only adults aged 18 and older can get the Moderna vaccine right now.

Some people should talk with their family doctor before getting the COVID-19 vaccine. This includes people who have severe reactions to injected medicines, people who are immunocompromised, and people who are pregnant or breastfeeding.

As with other vaccines, people who have an allergy to any part of the vaccine should not get the shot. People who have a fever or other symptoms may not be able to get the vaccine until they’re better.

How do I report side effects after getting the vaccine?

If you have side effects (also called adverse events) after getting the COVID-19 vaccine, you should report them to the Vaccine Adverse Event Reporting System (VAERS). Talk with your family doctor if you have questions about what might be considered a side effect related to the vaccine.

The CDC will also be using a new smartphone-based tool called v-safe to send text messages to encourage people to report any side effects. Information on v-safe will be given to everyone who gets the COVID-19 vaccine. You will also get a card that tells you which vaccine and dose you were given and provides other information about the vaccine. You must opt in to get v-safe text messages on your smartphone.